Monday, June 1, 2009

Comments from Google Site

I have a Google Site at which I am trying to topically arrange info on the cholinesterase inhibitor issue. (Yeah, I know I mention it in almost every blog post -- that's the main thing I'm interested in at the moment.)

Unfortunately it turns out that Google Sites does not support comments from anyone other than owners or collaborators. I found a forum thread that addresses this issue, and it basically says: Blogger is for comments; Sites isn't. Therefore this Blogger post is intended as a place where people can comment on my Sites pages.

Please comment here!


  1. Good afternoon,
    My mum was mistakenly diagnosed with Alzheimers. She has been taking REminyl xl for 7 years (In addition to nitrazepam and celexa) She does not have Alzheimers.
    We have reduced Benzo and ssri levels c 75% however we still have weak muscle and cognitive difficulties.
    She becomes very much weaker at the peak galantamine release.

    How do we get of it ????

    +441257 474663
    +4477930 55399

    I will call back

  2. My son was poisoned by iodophenfos and dichlorvos at the age of 8, he is now 24.He used 3/4 litre if Nuvan Staykil on an ants nest. He is very ill and has been diagnosed with multiple allergies to foods and chemicals which can provoke a psychosis, Today sadly we had to take him to hospital as he has had a terrible reaction to eating paprika in a homemade paella. He is in the psychiatric ward tonight after suffering delusions. Despite diagnosis from world experts doctors do not know what to do. It is made worse because we had made a breakthrough by giving him 5HTP since the first of March and we had our son back. Any ideas or help welcome. We are in France but are English (Jersey) by birth. Any scientific papers to give the doctors please.

  3. I have a daughter recently diagnosed with Celiac Disease. Her symptoms were neurological and some of them cleared up quickly, but the fatigue, brain fog, nausea and muscle tremors did not. After a 3 week elimination diet, it became clear that nightshades were the cause of these symptoms. It is harder than heck to get a medical doctor to believe this, however. I read your site with avid fascination, and am still digesting this info. Do you know of any doctors that are investigating this issue? Keep up the good work, and God bless you for posting this on the internet!
    Elizabeth in Auburn Hills, MI USA

  4. Sorry it took so long for me to notice this. I hadn't checked back there for a while, and apparently it doesn't send me email when people comment.

    @Anne: I'm sorry to hear about your son's difficulties. This paper may be useful: It's a case study of some people experiencing extreme responses to organophosphate exposure.

    Your son being hypersensitive to cholinesterase inhibitors/nightshade would potentially be consistent with what you describe. If that is the case, the only thing I have found that may help is to try to reduce exposure to cholinesterase inhibitors in the environment and diet. This is discussed at

    @Elizabeth: Thank you for your kind words. I hope your daughter is improving now that you have figured about the nightshade. Unfortunately I have not yet found a doctor that is investigating this issue. I have found papers from some researchers, particularly Dr. Hermona Soreq, that look potentially relevant, but unfortunately they do not seem to be focusing on dietary exposure. I would love to correspond further with you and your daughter.

  5. Oh, My, Goodness!!!!!
    After 15 years of fighting what we thought was hidden MSG, your site is beginning to shed light on what my husband, a 1991 Gulf War veteran experiences constantly. THANK YOU SO MUCH for all the info on CIs--I will be thoroughly researching what you've put out here, so we can finally have some answers!!! The only help I had ever found was the MSG Myth website, which is excellent. Yes, the only thing that keeps my husband out of what I call an "awake coma" is avoidance of absolutely everything you've listed in your articles--I'd never read or heard about Nightshade Sensitivity--his doctors,even a holistic doctor never mentioned it. Please keep up the work you do.
    Hannah, Birmingham, Alabama

  6. Thank you for taking the time to post all of your research. You have given me great insight into my potato sensitivity. I learned to avoid potato many years ago because of the brain fog and heat racing (anxiety like) reaction to it. My grandmother had nightshade sensitivity and now it all makes perfect sense.

    Perhaps now I can minimize all those unexpected reactions. :)

    Blessings to you. Be Well,

  7. I just found your info online. I was led to it by this article:
    I think you will find this interesting. I don't have problems with chemicals, but I am sensitive to wireless. This article talks about cholinesterase inhibitors and how environmental EMF can inhibit cholinesterase. It's not just diet it or pesticides it seems. This means that those living with a lot of wireless around them (routers, cell phones, alarm systems, etc.) may get some relief from limiting personal exposure, something we all have some ability to do.
    I'll keep reading, looks like you've got a wealth of info. Thanks for your kind service to us all.

    1. Please be aware that organophosphate pesticides are all over the place and should be avoided by those with this gene mutation. GMO plants are "Roundup Ready," meaning they have a high amount of organophosphates on them. Wheat is not GMO but in the USA and England, Wheat is heavily sprayed with organophosphates a few days before it is harvested, and then the organophosphate is in the wheat seeds and gets ground up in the flour. (This process is known in the industry as "desication" or "ripening.") This is the real reason many people feel better when they avoid wheat--it's not the gluten, it's the Roundup. Also get a list of GMO foods--that is also where the organophosphates are highest.

  8. This comment has been removed by the author.

  9. Check out fasciculations for reference. Thank you for sharing this kind of information.

    More power to your blog!

  10. My friend Anne asked that I let you know this since blogger isn't working for her.

    Please have her contact me thru my Greenchild Creations page, easiest way for us to get in touch - if she writes "hi" on my GC wall then I should be able to message her thru Facebook.

  11. Thanks miracle receiver. I did as you suggested and look forward to hearing from Anne.

    It was odd: initially there did not appear to be a way for me to post on her wall. Then after I clicked "Like" a box appeared that did let me write on her wall. I don't know if it's Facebook or Chrome that's acting strange.

    I had problems too trying to leave a comment on her blog using Chrome. I did get it to work using Safari. I wonder if she's experiencing the same problem.

  12. In the process of withdrawing from St. John's Wort in 2009, I began to have problems with having too much acetylcholine so I stopped eating fish, eggs, milk, beans, most nuts. Now I can only eat a few things. My levels are still not back to normal yet. It is a struggle as I keep losing weight. Thanks for your site. I'll definitely quit broccoli - but I wonder is it the pesticides they put on the food or the food itself?

  13. Hi Anne. Thank you so very much for sharing your knowlege of cholinesterase inhibitors. Hopefully you're still checking this page as I would be so appreciative if I could ask you some questions. Both my children have been diagnosed with Cholinesterase Deficiency inherited from their father and grandparents. My daughter's serum level is woefully low and I have been unsuccessful in obtaining any information at all from her doctors. They simply said "Do not under any circumstances let her come into contact with pesticides." Of course now that I've done some research I know that it goes much further than that. Would you mind if I emailed you or phoned with a few questions? I'll keep it as short and sweet as possible! Many thanks, Kath.

  14. Hi Anne,

    I stumbled upon Dr. Childers website after years of suffering from psoriatic arthritis. (When first diagnosed, fibromyalgia was a maybe.)

    At the time of finding his website, I was incapacitated with pain. I had put myself on a nutrient-dense plant based diet, and was flooding my body with nightshades and additional foods that contain solanine.

    I stopped ingesting all possible sources of solanine and my pain levels went from an 8 down to 2/3 in several days. I've been medication free for over a year, am still suffering with psor a, but have resumed a much higher level of functioning.

    I have been researching solanine in foods and can share some references with you. I was unable to find your Silverstone reference and would like to read that as well, if you could please advise.

    Two solanacea genus plants that are predominate in the health community these days are:
    ashwaghanda and gogi berries.

    I've cross referenced a few non-nightshades that containe solanine:
    apples, blueberries/huckleberries, artichoke and okra.

    Thanks for your excellent article,

  15. I am suffering from pesticide toxicity. I would very much like to know where you got the information on how CIs affect the various body symptoms. This would be very helpful to me as I am preparing a lawsuit against the plant nursery next to my home and need scientific references.
    You may check out my website at NoPesticidesMoorpark dot com and email me at diana_slater at

  16. I have had psoriasis for a long time and I had heard of the link between psoriasis and nightshades but never attempted to remove them from the diet. Well, and I found out a few years ago that I have low blood serum cholinesterase. But only yesterday did I discover that the nightshades have cholinesterase inhibitors in them. Now I will be A LOT more motivated to remove them from my diet. Thank you for your site. Reading about the negative effects of not having the acetylcholine breakdown properly made me feel like maybe that's why I've been inefficient at handling stress and muscular pain/discomfort. It helps to know there might be a real reason and it is not all in your head.

  17. Just started a nightshade exclusion diet to see if it helps with neuromyotonia. In preparing for it, I've also identified caffeine (coffee, chocolate, green tea) as cholinesterase inhibitors so will be excluding them also.

  18. Thank you for your informative article. I have recently discovered my sensitivity to all nightshade foods with inflammation and eczema in just my feet and all-over body joint pain. I am especially sensitive to potato. There are so many foods I have to avoid that it can be depressing. The alternative with the health problems is by far worse, though. I wanted to let you know that I have reacted to the non nightshade foods that contain solanine such as artichoke and sugar beets. I have a different kind of reaction to strawberries. I don't seem to have a problem with blueberries. I am wondering, if I eliminate all nightshades for a lengthy period of time, do you think my sensitivity could eventually subside? Thanks

    1. Strawberries and sugar beets have high levels of Roundup pesticide, an organophosphate. Sugar Beets are GMO foods, that is why. Get a list of all the GMO foods, as they are the highest in organophosphates. So is wheat, because it is sprayed with Roundup a few days before it is harvested, a process called
      "desiccation." Organic wheat or wheat from Italy may be fine. Also be aware that animal fats contain organophosphates because the feed they eat is high in organophosphates, and it ends up mostly in their fat. So in addition to avoiding nightshades, persons with this mutation should avoid: Wheat; GMO foods (get lists online); and animal fats. I also feel awful after eating chemicals in foods in general, like Nitrites in processed meat, MSG, etc.

  19. I have greatly enjoyed your insights and I wonder if you are aware that habitual caffeine use further skews the ACh/DA ratio, at least in rats. Here is the link for the study.
    J. Wall

  20. Congrats on your text on cholinesterase inhibitors! By far the best!!

    Cholinestersase levels can be tested in serum and in rbc as well. What do you think, which of these would be better to exclude issues with cholinesterase-inhibitors? That is, if a person consumes cholinesterase inhibitors (coffeine, ... chili, ... potatoes) then which cholinesterase would go down, if any?

    Also, you mention genes. Is there a genetic test available for these?

  21. Interesting
    I'm rs1799807(A;G)(0.7%)
    Mother had serious complications during an operation with 'Scolin' which I believe is Succinylcholine.
    I personally get nocturnal joint swelling and myoclunus , idopathic currently, still working on correlation to diet

    1. James, I have exactly the same profile as you! It is atypical BuChE with the K variant. Also check your SOD2 status; you can do that on Livewello--not sure about Promethease. It confers difficulty in breaking down toxins. I have the misfortune to be homozygous for that mutation. I thank God that I found all this stuff out, having suffered grievously for so long. Now I know what to avoid. It is a long list, but I can find a normal life when I do. See my comments above on GMO's, wheat, and Roundup.

    2. Hi, I also have A-TYPICAL BuChE. I have been wanting to find others with it, so we can help each other out. Are either of you on Facebook? I set up a group for discussing this topic.

    3. Yes! Omg I need to be a part of this!

    4. Hi Lisa - I really want to connect with other people about this. I made a nightshade free action yet. Please join so we can share information. Here's the group link on Facebook:

  22. Hi Anne,
    I have come across your cholinesterase inhibitor site and found it very useful. I have been researching this extensively as both a patient with extremely severe CIS (love your term) and I am also a nutritional medicine practitioner in Australia with specialisation in complex chronic disease and methylation. I would love to get in touch with you as I can clarify some of your questions/suspicions on your page, particularly with regard to which foods do contain CIs and which are usually better tolerated. This week's experiment: artichokes. Epic fail. I have tested all the others and more that you haven't listed as well. I Also have a comprehensive list of medicinal herbs that should be avoided by those with CIS if this interests you. If you'd like to get in touch to flesh out your work to help more people then let me know. Feel free to email me or contact me via my website

  23. Keep in mind that you can lessen the effects of solanine in potatoes by cutting off any part with green in it, and cutting out all the little buds. It is the green parts and buds that mostly have the solanine.

    I have the gene for this problem (rs1799807 A;G) but if I follow this step, I can usually eat potatoes with no problem. Also I can eat tomatoes, but very concentrated tomatoes in tomato paste will give me a mild headache.

    The South American Indian natives developed a method involving freezing potatoes to remove the solanine. I saw it on a PBS program, and if anyone can report on this method, it would be helpful.

    Thank you Anne for all your fine work here.


  24. Hello, a couple of years ago I did genetic testing and waa told I have Psuedocholinesterase Deficiency. I was told it was nothing to worry about, except certain types of anesthesia may affect me differently. When I googled it, that's all I could find.

    I've suffered from back, neck pain and fatigue my entire adult life. Nothing helped. My fatigue and pain got worse, and joint pain set in. I couldn't function anymore. I had a brand new baby and had just gone back to work. I had to stop working, it was all too much.

    Then I reread up on Psuedocholinesterase deficiency again and found the information about nightshades. I cut them out of my diet. Two weeks later, I felt like myself again and all the pain was gone.

    I've been accidentally poisoned by food based vitamins, hidden potato starch, and restaurants not taking my intolerance seriously. I notice within a few hours, but 24-48 hours it's at it's peak. Migraines, back pain, neck pain, joint pain, insomnia, fatgiue, anxiety all set in. After 7 days the only noticable symptom is fatigue and that lasts for an additional 7 days.

    Now I'm wondering if I do not have a gluten intolerance and it was just the nightshades this entire time.

    You've done some great work, thank you for this information.

  25. Since posting my last comment, I've made a new discovery. I've been accidentally poisoned a few times since then. I had a reaction to eye dilation drops. I've learned that the belladonna plant was used to dilate eyes and the current drops are a synthetic form. They must be cholinesterase inhibitors?

    I also found a nightshade free group where some members shared that they take high doses of vitamin C to reduce their reaction to nightshades. I tested this out the last two times I accidentally ingested nightshades and it worked. I took 4,000 mg of Buffered Vitamin C after realizing feta cheese has potato starch. I had neck pain, back pain, hand and foot pain, and I was yawning like crazy. After taking the C, the yawning subsided. The pain continued. The next day I was noticeably better. After taking the C daily, pain and fatigue is gone in 3-5 days. WAY better than the 7-14 days it took to recover before. I've also read that vitamin K can help too.