I have a Google Site at which I am trying to topically arrange info on the cholinesterase inhibitor issue. (Yeah, I know I mention it in almost every blog post -- that's the main thing I'm interested in at the moment.)
Unfortunately it turns out that Google Sites does not support comments from anyone other than owners or collaborators. I found a forum thread that addresses this issue, and it basically says: Blogger is for comments; Sites isn't. Therefore this Blogger post is intended as a place where people can comment on my Sites pages.
Please comment here!
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Good afternoon,
ReplyDeleteMy mum was mistakenly diagnosed with Alzheimers. She has been taking REminyl xl for 7 years (In addition to nitrazepam and celexa) She does not have Alzheimers.
We have reduced Benzo and ssri levels c 75% however we still have weak muscle and cognitive difficulties.
She becomes very much weaker at the peak galantamine release.
How do we get of it ????
Steve
+441257 474663
+4477930 55399
I will call back
Stephenlaycock@btinternet.com
My son was poisoned by iodophenfos and dichlorvos at the age of 8, he is now 24.He used 3/4 litre if Nuvan Staykil on an ants nest. He is very ill and has been diagnosed with multiple allergies to foods and chemicals which can provoke a psychosis, Today sadly we had to take him to hospital as he has had a terrible reaction to eating paprika in a homemade paella. He is in the psychiatric ward tonight after suffering delusions. Despite diagnosis from world experts doctors do not know what to do. It is made worse because we had made a breakthrough by giving him 5HTP since the first of March and we had our son back. Any ideas or help welcome. We are in France but are English (Jersey) by birth. Any scientific papers to give the doctors please.
ReplyDeleteI have a daughter recently diagnosed with Celiac Disease. Her symptoms were neurological and some of them cleared up quickly, but the fatigue, brain fog, nausea and muscle tremors did not. After a 3 week elimination diet, it became clear that nightshades were the cause of these symptoms. It is harder than heck to get a medical doctor to believe this, however. I read your site with avid fascination, and am still digesting this info. Do you know of any doctors that are investigating this issue? Keep up the good work, and God bless you for posting this on the internet!
ReplyDeleteElizabeth in Auburn Hills, MI USA
Sorry it took so long for me to notice this. I hadn't checked back there for a while, and apparently it doesn't send me email when people comment.
ReplyDelete@Anne: I'm sorry to hear about your son's difficulties. This paper may be useful: http://www.neurology.org/cgi/content/abstract/52/7/1467 It's a case study of some people experiencing extreme responses to organophosphate exposure.
Your son being hypersensitive to cholinesterase inhibitors/nightshade would potentially be consistent with what you describe. If that is the case, the only thing I have found that may help is to try to reduce exposure to cholinesterase inhibitors in the environment and diet. This is discussed at http://sites.google.com/site/annerwright/avoiding-cholinesterase-inhibitors
@Elizabeth: Thank you for your kind words. I hope your daughter is improving now that you have figured about the nightshade. Unfortunately I have not yet found a doctor that is investigating this issue. I have found papers from some researchers, particularly Dr. Hermona Soreq, that look potentially relevant, but unfortunately they do not seem to be focusing on dietary exposure. I would love to correspond further with you and your daughter.
Dear Anne, I'm so glad to found your information about BCHE. I researched many scientific articles and found more foods which inhibit ACHE and BCHE. I found no other email to contact you.
DeleteMerry Christmas and a Happy New Year 2021.
Michaela Stiller from Germany
Oh, My, Goodness!!!!!
ReplyDeleteAfter 15 years of fighting what we thought was hidden MSG, your site is beginning to shed light on what my husband, a 1991 Gulf War veteran experiences constantly. THANK YOU SO MUCH for all the info on CIs--I will be thoroughly researching what you've put out here, so we can finally have some answers!!! The only help I had ever found was the MSG Myth website, which is excellent. Yes, the only thing that keeps my husband out of what I call an "awake coma" is avoidance of absolutely everything you've listed in your articles--I'd never read or heard about Nightshade Sensitivity--his doctors,even a holistic doctor never mentioned it. Please keep up the work you do.
Hannah, Birmingham, Alabama
hannah@trawicks.com
Thank you for taking the time to post all of your research. You have given me great insight into my potato sensitivity. I learned to avoid potato many years ago because of the brain fog and heat racing (anxiety like) reaction to it. My grandmother had nightshade sensitivity and now it all makes perfect sense.
ReplyDeletePerhaps now I can minimize all those unexpected reactions. :)
Blessings to you. Be Well,
Bronwyn
I just found your info online. I was led to it by this article:
ReplyDeletehttp://www.scribd.com/doc/29418176/Microwaves-Imitate-Pesticides
I think you will find this interesting. I don't have problems with chemicals, but I am sensitive to wireless. This article talks about cholinesterase inhibitors and how environmental EMF can inhibit cholinesterase. It's not just diet it or pesticides it seems. This means that those living with a lot of wireless around them (routers, cell phones, alarm systems, etc.) may get some relief from limiting personal exposure, something we all have some ability to do.
I'll keep reading, looks like you've got a wealth of info. Thanks for your kind service to us all.
Holland
Please be aware that organophosphate pesticides are all over the place and should be avoided by those with this gene mutation. GMO plants are "Roundup Ready," meaning they have a high amount of organophosphates on them. Wheat is not GMO but in the USA and England, Wheat is heavily sprayed with organophosphates a few days before it is harvested, and then the organophosphate is in the wheat seeds and gets ground up in the flour. (This process is known in the industry as "desication" or "ripening.") This is the real reason many people feel better when they avoid wheat--it's not the gluten, it's the Roundup. Also get a list of GMO foods--that is also where the organophosphates are highest.
DeleteThis comment has been removed by the author.
ReplyDeleteCheck out fasciculations for reference. Thank you for sharing this kind of information.
ReplyDeleteMore power to your blog!
My friend Anne asked that I let you know this since blogger isn't working for her.
ReplyDeletePlease have her contact me thru my Greenchild Creations page, http://www.facebook.com/pages/Greenchild-Creations/107770265962471?ref=hnav easiest way for us to get in touch - if she writes "hi" on my GC wall then I should be able to message her thru Facebook.
Thanks miracle receiver. I did as you suggested and look forward to hearing from Anne.
ReplyDeleteIt was odd: initially there did not appear to be a way for me to post on her wall. Then after I clicked "Like" a box appeared that did let me write on her wall. I don't know if it's Facebook or Chrome that's acting strange.
I had problems too trying to leave a comment on her blog using Chrome. I did get it to work using Safari. I wonder if she's experiencing the same problem.
In the process of withdrawing from St. John's Wort in 2009, I began to have problems with having too much acetylcholine so I stopped eating fish, eggs, milk, beans, most nuts. Now I can only eat a few things. My levels are still not back to normal yet. It is a struggle as I keep losing weight. Thanks for your site. I'll definitely quit broccoli - but I wonder is it the pesticides they put on the food or the food itself?
ReplyDeleteHi Anne. Thank you so very much for sharing your knowlege of cholinesterase inhibitors. Hopefully you're still checking this page as I would be so appreciative if I could ask you some questions. Both my children have been diagnosed with Cholinesterase Deficiency inherited from their father and grandparents. My daughter's serum level is woefully low and I have been unsuccessful in obtaining any information at all from her doctors. They simply said "Do not under any circumstances let her come into contact with pesticides." Of course now that I've done some research I know that it goes much further than that. Would you mind if I emailed you or phoned with a few questions? I'll keep it as short and sweet as possible! Many thanks, Kath.
ReplyDeleteflykathfly@gmail.com
Hi Anne,
ReplyDeleteI stumbled upon Dr. Childers website after years of suffering from psoriatic arthritis. (When first diagnosed, fibromyalgia was a maybe.)
At the time of finding his website, I was incapacitated with pain. I had put myself on a nutrient-dense plant based diet, and was flooding my body with nightshades and additional foods that contain solanine.
I stopped ingesting all possible sources of solanine and my pain levels went from an 8 down to 2/3 in several days. I've been medication free for over a year, am still suffering with psor a, but have resumed a much higher level of functioning.
I have been researching solanine in foods and can share some references with you. I was unable to find your Silverstone reference and would like to read that as well, if you could please advise.
Two solanacea genus plants that are predominate in the health community these days are:
ashwaghanda and gogi berries.
I've cross referenced a few non-nightshades that containe solanine:
apples, blueberries/huckleberries, artichoke and okra.
Thanks for your excellent article,
Jen
jlsiskind@cox.net
I am suffering from pesticide toxicity. I would very much like to know where you got the information on how CIs affect the various body symptoms. This would be very helpful to me as I am preparing a lawsuit against the plant nursery next to my home and need scientific references.
ReplyDeleteYou may check out my website at NoPesticidesMoorpark dot com and email me at diana_slater at att.net.
I have had psoriasis for a long time and I had heard of the link between psoriasis and nightshades but never attempted to remove them from the diet. Well, and I found out a few years ago that I have low blood serum cholinesterase. But only yesterday did I discover that the nightshades have cholinesterase inhibitors in them. Now I will be A LOT more motivated to remove them from my diet. Thank you for your site. Reading about the negative effects of not having the acetylcholine breakdown properly made me feel like maybe that's why I've been inefficient at handling stress and muscular pain/discomfort. It helps to know there might be a real reason and it is not all in your head.
ReplyDeleteJust started a nightshade exclusion diet to see if it helps with neuromyotonia. In preparing for it, I've also identified caffeine (coffee, chocolate, green tea) as cholinesterase inhibitors so will be excluding them also.
ReplyDeleteThank you for your informative article. I have recently discovered my sensitivity to all nightshade foods with inflammation and eczema in just my feet and all-over body joint pain. I am especially sensitive to potato. There are so many foods I have to avoid that it can be depressing. The alternative with the health problems is by far worse, though. I wanted to let you know that I have reacted to the non nightshade foods that contain solanine such as artichoke and sugar beets. I have a different kind of reaction to strawberries. I don't seem to have a problem with blueberries. I am wondering, if I eliminate all nightshades for a lengthy period of time, do you think my sensitivity could eventually subside? Thanks
ReplyDeleteStrawberries and sugar beets have high levels of Roundup pesticide, an organophosphate. Sugar Beets are GMO foods, that is why. Get a list of all the GMO foods, as they are the highest in organophosphates. So is wheat, because it is sprayed with Roundup a few days before it is harvested, a process called
Delete"desiccation." Organic wheat or wheat from Italy may be fine. Also be aware that animal fats contain organophosphates because the feed they eat is high in organophosphates, and it ends up mostly in their fat. So in addition to avoiding nightshades, persons with this mutation should avoid: Wheat; GMO foods (get lists online); and animal fats. I also feel awful after eating chemicals in foods in general, like Nitrites in processed meat, MSG, etc.
I have greatly enjoyed your insights and I wonder if you are aware that habitual caffeine use further skews the ACh/DA ratio, at least in rats. Here is the link for the study. http://www.ncbi.nlm.nih.gov/pubmed/12093592
ReplyDeleteRegards,
J. Wall
Congrats on your text on cholinesterase inhibitors! By far the best!!
ReplyDeleteCholinestersase levels can be tested in serum and in rbc as well. What do you think, which of these would be better to exclude issues with cholinesterase-inhibitors? That is, if a person consumes cholinesterase inhibitors (coffeine, ... chili, ... potatoes) then which cholinesterase would go down, if any?
Also, you mention genes. Is there a genetic test available for these?
Interesting
ReplyDeleteI'm rs1799807(A;G)(0.7%)
rs28933390(G;G)
rs28933389(C;C)
rs1803274(A;G)
Mother had serious complications during an operation with 'Scolin' which I believe is Succinylcholine.
I personally get nocturnal joint swelling and myoclunus , idopathic currently, still working on correlation to diet
James, I have exactly the same profile as you! It is atypical BuChE with the K variant. Also check your SOD2 status; you can do that on Livewello--not sure about Promethease. It confers difficulty in breaking down toxins. I have the misfortune to be homozygous for that mutation. I thank God that I found all this stuff out, having suffered grievously for so long. Now I know what to avoid. It is a long list, but I can find a normal life when I do. See my comments above on GMO's, wheat, and Roundup.
DeleteHi, I also have A-TYPICAL BuChE. I have been wanting to find others with it, so we can help each other out. Are either of you on Facebook? I set up a group for discussing this topic.
DeleteYes! Omg I need to be a part of this!
DeleteHi Lisa - I really want to connect with other people about this. I made a nightshade free group....no action yet. Please join so we can share information. Here's the group link on Facebook: https://www.facebook.com/groups/1833080330324006/
DeleteHi Anne,
ReplyDeleteI have come across your cholinesterase inhibitor site and found it very useful. I have been researching this extensively as both a patient with extremely severe CIS (love your term) and I am also a nutritional medicine practitioner in Australia with specialisation in complex chronic disease and methylation. I would love to get in touch with you as I can clarify some of your questions/suspicions on your page, particularly with regard to which foods do contain CIs and which are usually better tolerated. This week's experiment: artichokes. Epic fail. I have tested all the others and more that you haven't listed as well. I Also have a comprehensive list of medicinal herbs that should be avoided by those with CIS if this interests you. If you'd like to get in touch to flesh out your work to help more people then let me know. Feel free to email me or contact me via my website https://www.anabundantlife.com.au
Keep in mind that you can lessen the effects of solanine in potatoes by cutting off any part with green in it, and cutting out all the little buds. It is the green parts and buds that mostly have the solanine.
ReplyDeleteI have the gene for this problem (rs1799807 A;G) but if I follow this step, I can usually eat potatoes with no problem. Also I can eat tomatoes, but very concentrated tomatoes in tomato paste will give me a mild headache.
The South American Indian natives developed a method involving freezing potatoes to remove the solanine. I saw it on a PBS program, and if anyone can report on this method, it would be helpful.
Thank you Anne for all your fine work here.
Elizabeth
Thick-peeling potatoes, boiling them in a lot of water (and throwing that water out) didn't help at all. I still react to them with severe depression and other symptoms. I even tried lacto-fermenting them, to no avail. The only way they seem OK to me, is deep fried (french fries). But then one has the other issue of eating deep fried in PUFA oil food.
DeleteHello, a couple of years ago I did genetic testing and waa told I have Psuedocholinesterase Deficiency. I was told it was nothing to worry about, except certain types of anesthesia may affect me differently. When I googled it, that's all I could find.
ReplyDeleteI've suffered from back, neck pain and fatigue my entire adult life. Nothing helped. My fatigue and pain got worse, and joint pain set in. I couldn't function anymore. I had a brand new baby and had just gone back to work. I had to stop working, it was all too much.
Then I reread up on Psuedocholinesterase deficiency again and found the information about nightshades. I cut them out of my diet. Two weeks later, I felt like myself again and all the pain was gone.
I've been accidentally poisoned by food based vitamins, hidden potato starch, and restaurants not taking my intolerance seriously. I notice within a few hours, but 24-48 hours it's at it's peak. Migraines, back pain, neck pain, joint pain, insomnia, fatgiue, anxiety all set in. After 7 days the only noticable symptom is fatigue and that lasts for an additional 7 days.
Now I'm wondering if I do not have a gluten intolerance and it was just the nightshades this entire time.
You've done some great work, thank you for this information.
Since posting my last comment, I've made a new discovery. I've been accidentally poisoned a few times since then. I had a reaction to eye dilation drops. I've learned that the belladonna plant was used to dilate eyes and the current drops are a synthetic form. They must be cholinesterase inhibitors?
ReplyDeleteI also found a nightshade free group where some members shared that they take high doses of vitamin C to reduce their reaction to nightshades. I tested this out the last two times I accidentally ingested nightshades and it worked. I took 4,000 mg of Buffered Vitamin C after realizing feta cheese has potato starch. I had neck pain, back pain, hand and foot pain, and I was yawning like crazy. After taking the C, the yawning subsided. The pain continued. The next day I was noticeably better. After taking the C daily, pain and fatigue is gone in 3-5 days. WAY better than the 7-14 days it took to recover before. I've also read that vitamin K can help too.
Hello! I just wanted to share a bit about my experience with a choline supplement.
ReplyDeleteI have Mast Cell Activation Syndrome, Ehlers-Danlos Syndrome, and Dysautonomia. I also have the SNP rs1799807(A;G)
(Heterozygous for 'atypical' BuChE) but I didn't now that at the time.
When I was researching supplements to help myself with these conditions (and my fatty liver!) I stumbled upon choline. As I was having some very strange and severe neurotransmitter storms of some kind during anaphylaxis from my MCAS, I thought I would give it a shot. I got a bottle for a months supply.
I went into remission after three days of a full dose daily. I felt better than I had in YEARS. Every aspect of my trifecta of health problems was better. Not 100 healed--I still minded my foods and whatnot and had problems if I didn't.....but I was absolutely in remission. My anaphylactic neuro storms STOPPED. I still had anaphylaxis but the crazy seizure-like activity was no more and my epi pen worked much more effectively.
Since I am on a limited budget, I ran out and have not been able to get more. I experienced a decline as it seemed to leave my system. The strange neuro storms during anaphylaxis are back.
I will be getting more as soon as I can.
Just my story :) I hope it helps simeone!
Cassie your experience surprises me greatly. I too am positive for atypical BCHE, and choline makes me SO DEPRESSED. Almost always the black mood is delayed...that is why it took me some time to discover the connection. I found lists online of foods high in choline, and I avoid them. The brain uses the choline in food to make the neurotransmitter Acetylcholine. AS ACETYLCHOLINE RISES, SEROTONIN FALLS-- thus depression in some persons, anxiety, anger, in others. MelanCHOLIa, get it? I researched this word. It is not a coincidence. The choline - depression connection was known by the ancient Greeks. Also beware of lecithin,as it is very high in choline.
ReplyDeleteHi Unknown,
DeleteI have not seen evidence of cholinergic synapse function going awry being related to dietary choline. The production of acetylcholine in cholinergic synapses is highly regulated. I don't think it's likely to go up and down depending on how much you eat.
A more likely culprit, I think, for issues with excessive cholinergic activation is cholinesterase inhibitors interfering with the breakdown of acetylcholine on the downstream side, not excessive production on the upstream side.
In fact, the most credible arguments I have seen regarding dietary choline are from Chris Masterjohn. He stresses the importance of eating enough choline in order to keep liver and gallbladder function working right and avoid fatty liver disease. More information on that topic is available here:
https://chrismasterjohnphd.com/2016/04/24/start-here-for-fatty-liver-disease/
I respect that dietary choline may be an issue for Unknown in regulating his/her mood. However, I caution readers that this may be idiosyncratic (as nightshade effects likely are for me and others with that sensitivity), and eating too little choline may have serious detrimental effects.
Anne
I have the same (depressed) reaction to choline and high choline foods
DeleteHi Anne, Finding the information on your website is life-changing for me. Having struggled with health problems for many years, discovering the link with nightshades around seven years ago led to a huge improvement. Along the way I have discovered other sensitivities - green tea, blueberries, grapes, strawberries, watermelon. I have been looking at lectin-rich foods as a possible culprit, but that hypothesis doesn't quite line up. However, your work does. Thanks for allowing others to benefit from your knowledge and all your work - and for not marketing it with an hour-long video that promises much but delivers nothing, unless you pay the price tag at the end!
ReplyDeleteThank you for all this great information! I have been nightshade free for several years now. I've gotten pretty good at it! Have you come across good information as to what to do should a person accidentally ingest nightshades, to prevent an attack? I usually take benadryl and immodium. I can only take bayer asprin for joint pain because I had a bad reaction to an extra strength tylenol once, and I suspected potato flour or some such. I've hear people take vitamin C, but if it is likely using nightshade as a source, that could be troublesome. I'm always searching for ways to help my body get through! Thank you again.
ReplyDeleteHi Unknown,
DeleteThank you for reaching out. This is a good question.
What I have used most recently to recover from an acute nightshade-related incident was:
* Taking a dose of [nicotinic form niacin](http://humansystemdebugging.blogspot.com/2013/11/new-potential-ha-niacin-sam-e-and.html)
* Eating a banana
* Taking a dose of Nyquil (contains doxylamine succinate, which is an anticholinergic)
* When muscle spasms are a major feature, I also take a dose of magnesium (I use [Amino-Mag 200](https://www.douglaslabs.com/amino-mag-200-trade.html))
At that point I pretty much always fall asleep, and wake up feeling better.
The Nyquil is a recent addition based on conversations with another commenter. It turns out to be anticholinergic (doxylamine succinate).
The rest have been my go-to strategy for about 10 years or so.
Hi Interesting. Had thought needed more acetylcholine. Can 1 be too high and then too low? Read/saw Driscol theory on YT she had severe constipation and used a nicotine patch(think she said needed choline and vite B1 helps make). Wish a chart of symptoms if hi or lo Ach as thought was low but get some joint pain from potatoes and tomatoes. Also from wheat, corn, but most all of these are high in oxalaic acid (very high in almonds,soy(not tempe). Read here and other vite C, K2 (grassfed butter,cheese,eggs,liver) help. On occacion leg cramps thought were dehydration or?, but Mg didnt work, pickle juice or dilute AC vin. Would like to wake up in morning refreshed (not at 2:47am like this am)and read could be from low histamine, and low AChe(hi Ach). WIll be nice to get things balance.
ReplyDeleteThis comment has been removed by the author.
ReplyDeleteHi Anne, many thanks for your valuable information. I am a nutritional therapist and for many years have been struggling with severe depression that 'normal' nutritional approaches have not worked to relieve. In Jan 2019 I stopped eating the Nightshade family after coming across your site and started taking Coleus Forskohlii supplements which have helped - Forskolin being the only plant ingredient that I could find that actually increases the much maligned AChE. I also suffer from peripheral neuropathy – a symptom of organophosphate/herbicide poisoning from many years spent as a gardener which is when this all started getting serious. I believe herbicides contributed to a natural predisposition which is now exacerbated by certain foods, alcohol and stress.
ReplyDeleteI recently found that rice contains high levels of arsenic – a compound that has been positively linked to low AChE levels. I have eaten a lot of rice because it is a mainstay of nutritional protocols but feel better for reducing my intake.
I have recently read research that claims that Limes and Lemon Balm are AChE inhibitors as well as flavonoids - in-particular quercetin which exhibited significant inhibitory activity of 76.2% against AChE. “Quercetin is contained in abundance in apples, honey, raspberries, onions, red grapes, cherries, citrus fruits, and green leafy vegetables. Among vegetables and fruits, quercetin content is highest in onions.” I’ve also read that regular consumption of caffeine in tea or coffee lowers AChE levels.
Hi Anne, thank you for putting all this information together. I now suspect I am very sensitive to acetylcholine, which goes hand in hand with my celiac artery compression diagnosis. I always thought it was so weird that fish oil and vitamin D and eating tons of blueberries and greens and so on made me feel like crap. What diet do you stick to now, after being able to tinker with it for years? Do you have a standard dietary staple plan for those of us with acetylcholine sensitivity? Also do you offer paid consultations? I would love to ask you a couple more questions and I would be happy to compensate you for your time. Please let me know. Thank you!
ReplyDeleteDear Anne, Thank you for your whole work. Your site was recommended at the selfhealing group nightshade free and cholinesterase inhibitor at Facebook. I opened a sealfhealing group in Germany and made a website about my cholinesterase https://mycholinesterase.de/ only in German and have an Instagram mycholinesterase. I researched many articles about cholinesterase inhibitors from plants and medication. If you are interested in please contact me at cholinesterase@gmx.de.
ReplyDeleteHi Anne,
ReplyDeleteI'm not sure if you're still checking comments, but I chatted w/you quite a bit about 11-12 years ago, and wanted to update you on some things you were looking into, but couldn't find answers way back then.
You asked where Gilbert found her info on blueberries, etc.. Actually now there are quite a few studies on blueberries and other high phenolic foods that block or strongly inhibit acetylcholinesterase. Often it has to do with the high tannin content of the skin of the fruit or vegetable. AcHE inhibitors are also found in many, many spices -- to different degrees -- but high in things like cinnamon, curcumin...almost anything with a strong taste and especially a tart, tannin-like flavor. The minerals zinc and copper also lower AcHE, as do INFECTIONS.
A google search will turn up these studies.
Also, l-carnitine, sodium butyrate, iron, butryicum probiotics (Miyarisan). tyrosine and b12 increase levels and/or activity of AChE.
Hope this is helpful, and hope to hear from you soon.
This comment has been removed by the author.
ReplyDeleteHello Anne. Just wanted to thank you for the tremendous amount of work you put into this. This is the most comprehensive source of information on AcHE and its inhibitors that I have found anywhere. Unfortunately, these days, your typical search engines only point to the top dozen or so accepted sites for health information, so sites like yours and many others are very difficult to find. I have found your information very helpful. Thanks again.
ReplyDelete